HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1901107Generated: November 3, 2026
Tributyltin Chloride → 4-(Tri-n-butylstannyl)pyridine
https://huagongshe.com/reaction/1901107
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tributyltin Chloride | HCID 15096 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 4-Bromopyridinium chloride | HCID 88100 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 4-(Tri-n-butylstannyl)pyridine | HCID 2737318 | — |
Reaction Steps
To a suspension of 4-bromopyridine hydrochloride (1.5 g) in Et2O (20 mL) at -78° C. was added n-BuLi (6.2 mL of a 2.5M solution). After 30 min. the mixture was warmed to -30° C., tributyltin chloride (2.1 mL) was added and the mixture warmed to 0° C. Saturated NH4Cl was added and extracted with Et2O. The organics were washed with H2O, brine, dried (MgSO4) and concentrated. Chromatography (silica gel; EtOAc/hexane (15:85)) provided the title compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05576338 |
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| Source dataset | uspto-grants-1996_11 |
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| ORD ID | ord-f75560f778c54679aed3b6aa8fc04d71 |
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| Source note | uspto-grants-1996_11 |
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