HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Tri-n-butylstannyl)pyridine → HCID 67747269, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Tri-n-butylstannyl)pyridine | HCID 2737318 | — |
| Reactant | 1-(Benzyloxy)-3-bromo-5-fluorobenzene | HCID 11254516 | — |
| Catalyst | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 67747269 | HCID 67747269 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of 4-tributylstannylpyridine (250 mg), O-benzyl-3-bromo-5-fluorophenol (200 mg; EP 385,662) and tetrakis (triphenylphosphine) palladium (8 mg) in dioxane (3 mL) was heated at 100° C. for 15 h. The solvent was evaporated and the residue chromatographed (silica gel; hexane/EtOAc acetate (4:1-3:2)) to provide the title compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05576338 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-58a19089502b48ba83f233e6ee65d590 |
| Source note | uspto-grants-1996_11 |