HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1901112Generated: October 30, 2026
Ethyl Acetate → S-(2-Trimethylsilylethyl)-3-fluoro-5-phenylthiophenol
https://huagongshe.com/reaction/1901112
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-(Trimethylsilyl)ethanethiol | HCID 205521 | — |
| Reactant | 3,5-Difluorobiphenyl | HCID 13022391 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | S-(2-Trimethylsilylethyl)-3-fluoro-5-phenylthiophenol | HCID 57070644 | — |
Reaction Steps
To a suspension of NaH (360 mg) in DMF (10 mL) at 0° C. was added 2-(trimethylsilyl)ethanethiol (1.8 mL). After 10 min., a solution of 1,3-difluoro-5-phenylbenzene (1.9 g) in DMF (5 mL) was added and the resulting mixture was heated at 110° C. for 2.5 h. Ethyl acetate was added and the solution was washed with 1N HCl, H2O and brine. Concentration and chromatography (silica gel; hexane/EtOAc (98:2)) provided the title compound as a liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05576338 |
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| Source dataset | uspto-grants-1996_11 |
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| ORD ID | ord-b5f33523b9b84f7daf7281a35877f702 |
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| Source note | uspto-grants-1996_11 |
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