4,7-Dichloroquinoline → 7-Chloro-4-iodoquinoline

Participants

Reaction Conditions

Reaction Steps

4,7-Dichloroquinoline (50 g) was added, in small portions, to HI (425 mL) at r.t. and then heated at 130° C. for 5 h. The mixture was cooled, poured into ice/H2O (600 mL), made basic (pH 10) with 10N NaOH, and extracted with CHCl3. The combined organics were washed with NH4OAc buffer, 10% Na2S2O3 and brine. Drying (Na2SO4) and concentration provided the title compound that was used as such.

Provenance & Evidence