M-Cresol → Cresatin

Participants

Reaction Steps

To a solution of m-cresol (Aldrich) (80 g, 0.74 mol) in dry CH2Cl2 (300 mL) and pyridine (71 mL, 0.89 mol) at 0° C. was added dropwise AcCl (58 mL, 0.81 mol). The reaction mixture was stirred for ca 1 h and then diluted with more CH2Cl2. The organic phase was washed successively with HCl 1N (3×), brine, dried over MgSO4 and evaporated. The residue was distilled under vacuum to give the title compound.

Provenance & Evidence