HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene → 2-[2-(4-Methoxycarbonylmethylphenoxy)-1-methylethyl]amino-1-(2-naphthyl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene | HCID 241 | — |
| Reactant | 2-Amino-1-(naphthalen-2-yl)ethan-1-ol | HCID 2735379 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | Methyl 4-(2-oxopropoxy)phenylacetate | HCID 21832178 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-[2-(4-Methoxycarbonylmethylphenoxy)-1-methylethyl]amino-1-(2-naphthyl)ethanol | HCID 53974928 | 51.2% |
Reaction Steps
Following a procedure similar to that described in Example 6, but using 3 g of 2-amino-1-(2-naphthyl)ethanol (prepared as described in Preparation 9), 3.87 g of methyl 4-(2-oxopropoxy)phenylacetate (prepared as described in Preparation 3), 60 ml of benzene, 50 ml of absolute methanol and 2.49 g of sodium cyanoborohydride, 3.23 g of the title compound were obtained having an Rf=0.15 (thin layer chromatography over silica gel, using ethyl acetate as the developing solvent).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05576340 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-12c4f4fe833f4709adb2c067033d5fb4 |
| Source note | uspto-grants-1996_11 |