HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene → HCID 22867075, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene | HCID 241 | — |
| Reactant | Phenylpropanolamine | HCID 10297 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | Methyl 4-(2-oxopropoxy)phenylacetate | HCID 21832178 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 22867075 | HCID 22867075 | 37.8% |
Reaction Steps
Following a procedure similar to that described in Example 6, but using 3 g of (1R,2S)-(-)-norephedrine, 4.36 g of methyl 4-(2-oxopropoxy)phenylacetate (prepared as described in Preparation 3), 60 ml of benzene, 50 ml of absolute methanol and 3.41 g of sodium cyanoborohydride, 2.65 g of the title compound were obtained as crystals, melting at 124° C. (after recrystallization from a mixture of ethyl acetate and hexane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05576340 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-a2a42550ca0d4ee698588bf90e667d18 |
| Source note | uspto-grants-1996_11 |