Fumaric Acid → HCID 21832182, compound

HRID 1901170Notes

Reaction equation

HRID 1901170 reaction equation
[CH3:1][O:2][C:3]([CH2:5][C:6]1[CH:26]=[CH:25][C:9]([O:10][CH2:11][CH:12]([NH:14][CH2:15][CH:16]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([Cl:24])[CH:19]=2)[OH:17])[CH3:13])=[CH:8][CH:7]=1)=[O:4].[C:27]([OH:34])(=[O:33])/[CH:28]=[CH:29]/[C:30]([OH:32])=[O:31]>CO>[C:27]([OH:34])(=[O:33])/[CH:28]=[CH:29]/[C:30]([OH:32])=[O:31].[CH3:1][O:2][C:3]([CH2:5][C:6]1[CH:26]=[CH:25][C:9]([O:10][CH2:11][CH:12]([NH:14][CH2:15][CH:16]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([Cl:24])[CH:19]=2)[OH:17])[CH3:13])=[CH:8][CH:7]=1)=[O:4]

Participants

4

Reactant 2

HCID 444972Fumaric AcidHCID 9907760HCID 9907760, compound

Product 1

HCID 21832182HCID 21832182, compoundYield 96.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 10.0 g of 2-[2-(4-methoxycarbonylmethylphenoxy)-1-methylethyl]amino-1-(3-chlorophenyl)ethanol (prepared as described in Example 3) and 2.8 g of fumaric acid was dissolved in methanol and then the methanol was removed by distillation under reduced pressure. The residue was recrystallized from ethyl acetate, to give 11.5 g of the title compound as crystals, melting at 130°-146° C.

Workup

  1. customthe methanol was removed by distillation under reduced pressure
  2. customThe residue was recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-9fe457bb64c54f419370bcefbf2b0d7a
Source dataset
uspto-grants-1996_11
Patent number
US05576340

Reaction notes

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