HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene → 2-[2-(4-Methoxycarbonylphenoxy)-1-methylethyl]amino-1-(3-chlorophenyl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene | HCID 241 | — |
| Reactant | 2-Amino-1-(3-chlorophenyl)ethan-1-ol | HCID 3751601 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | Methyl 4-(2-oxopropoxy)benzoate | HCID 21832186 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-[2-(4-Methoxycarbonylphenoxy)-1-methylethyl]amino-1-(3-chlorophenyl)ethanol | HCID 21832173 | — |
Reaction Steps
A procedure similar to that described in Example 12 was repeated, except that 3.43 g of 2-amino-1-(3-chlorophenyl)ethanol (prepared as described in Preparation 8), 4.5 g of methyl 4-(2-oxopropoxy)benzoate (prepared as described in European Patent Publication No. 6735), 100 ml of benzene, 100 ml of absolute methanol and 2.7 g of sodium borohydride were used, to give the title compound as crystals, melting at 99°-101° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05576340 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-e790249af1de4ea4b344daf7e138c381 |
| Source note | uspto-grants-1996_11 |