HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium cyanoborohydride → N-[2-(4-methoxycarbonylmethylphenoxy)-1(S)-methylethyl]-2(R)-t-butyldimethylsilyloxy-2-phenylethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | (R)-alpha-(t-Butyldimethylsilyloxy)-alpha-phenylacetaldehyde | HCID 10933947 | — |
| Reactant | Methyl 4-[2(S)-amino-1-propoxy]phenylacetate | HCID 22867084 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-[2-(4-methoxycarbonylmethylphenoxy)-1(S)-methylethyl]-2(R)-t-butyldimethylsilyloxy-2-phenylethanamine | HCID 22867087 | — |
Reaction Steps
Following a procedure similar to that described in Preparation 29, but using 750 mg of (R)-α-(t-butyldimethylsilyloxy)-α-phenylacetaldehyde (prepared as described in Preparation 25), 920 mg of methyl 4-[2(S)-amino-1-propoxy]phenylacetate (prepared as described in Preparation 28), 10 ml of absolute methanol and 500 mg of sodium cyanoborohydride, the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05576340 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-4b3a959b8daf425785ca797d7f5b5d54 |
| Source note | uspto-grants-1996_11 |