(Aminomethyl)phosphonic acid → Glyphosate

HRID 1901389Notes

Reaction equation

HRID 1901389 reaction equation
[NH2:1][CH2:2][P:3](=[O:6])([OH:5])[OH:4].O.[C:8]([OH:12])(=[O:11])[CH:9]=O.[H][H]>>[CH2:9]([NH:1][CH2:2][P:3]([OH:5])([OH:4])=[O:6])[C:8]([OH:12])=[O:11]

Participants

4

Reactant 3

HCID 14017(Aminomethyl)phosphonic acidHCID 15620607Glyoxylic acid, monohydrateHCID 178418361HCID 178418361, compound

Product 1

HCID 3496GlyphosateYield 96%

Procedure

Aminomethylphosphonic acid and glyoxylic acid hydrate were reacted under catalytic hydrogenation conditions in the manner described in Example 2, except prior to introduction of hydrogen, the pH was adjusted to 8.0. A 96% yield of glyphosate was obtained.

Sources & evidence

ORD record
ord-65d1b159d23c469783c66d16105bfe6a
Source dataset
uspto-grants-1996_11
Patent number
US05578190

Reaction notes

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