Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1901390Generated: November 3, 2026

Formic Acid → N-Formyl-N-phosphonomethylglycine

https://huagongshe.com/reaction/1901390

Reaction equation

Participants

RoleNameHCIDCharge
ReactantFormic AcidHCID 284—
Reactant(Aminomethyl)phosphonic acidHCID 14017—
ReactantGlyoxylic acid, monohydrateHCID 15620607—
ProductN-Formyl-N-phosphonomethylglycineHCID 13920556—

Reaction Conditions

Temperature80 °C

Reaction Steps

Aminomethylphosphonic acid (3.12 g, 0.028 mol) was dissolved in 30 ml of stirred 98% formic acid maintained at 80° C. with an oil bath. Glyoxylic acid hydrate (5.60 g, 0.061 mol) was added to the solution in several portions, resulting in vigorous gas evolution. After one hour, the reaction flask was removed from the oil bath and the solvent removed on a rotary evaporator to afford crude N-formyl-N-phosphonomethylglycine as a viscous yellow oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05578190
Source datasetuspto-grants-1996_11
ORD IDord-06011e2e17d343abbd3d18dfcde7a361
Source noteuspto-grants-1996_11