Sodium Hydroxide → HCID 131719723, compound

HRID 1901411Notes

Reaction equation

HRID 1901411 reaction equation
C[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([N:9]([C:25](=[O:32])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]C)[C:10](=[O:24])[CH2:11][CH2:12][CH2:13][CH2:14][C@H:15]1[C@@H:23]2[C@@H:18]([NH:19][C:20]([NH:22]2)=[O:21])[CH2:17][S:16]1)=[O:8].[OH-].[Na+]>CO>[CH3:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([N:9]([C:25](=[O:32])[CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[C:10](=[O:24])[CH2:11][CH2:12][CH2:13][CH2:14][C@H:15]1[C@@H:23]2[C@@H:18]([NH:19][C:20]([NH:22]2)=[O:21])[CH2:17][S:16]1)=[O:8]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 131719724HCID 131719724, compound

Product 1

HCID 131719723HCID 131719723, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 610 mg (0.819 mmol) of N,N-bis-(methyl 6-hexanoyl)-biotinamide in 35 ml of methanol was added 5.0 ml of 1N aqueous sodium hydroxide. The mixture was stirred at 15°-25° C. for 4.5 hours and then concentrated. The residue was diluted with 50 ml of deionized water acidified to pH 2 with 1N aqueous hydrochloric acid at 4° C. The product, which precipitated out as a white solid, was isolated by vacuum filtration and dried under vacuum to afford 482 mg (84%):

Workup

  1. concentrationconcentrated
  2. additionThe residue was diluted with 50 ml of deionized water
  3. customacidified to pH 2 with 1N aqueous hydrochloric acid at 4° C
  4. customThe product, which precipitated out as a white solid
  5. customwas isolated by vacuum filtration
  6. customdried under vacuum
  7. customto afford 482 mg (84%)

Sources & evidence

ORD record
ord-4cb7c48e3c6447e89ad0c2df41bce40b
Source dataset
uspto-grants-1996_11
Patent number
US05578287

Reaction notes

Loading…