HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1901414Generated: October 31, 2026
HCID 178439009, compound → HCID 178439004, compound
https://huagongshe.com/reaction/1901414
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | HCID 178439009 | HCID 178439009 | — |
| Reactant | HCID 178460924 | HCID 178460924 | — |
| Catalyst | Dichloro(1,1'-(1,3-propanediyl)bis(1,1-diphenylphosphine-kappaP))nickel | HCID 2724937 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178439004 | HCID 178439004 | 70% |
Reaction Steps
An 22-ml tetrahydrofuran solution of 1.05M 4-(2-(4-n-propylphenyl)ethyl)phenyl magnesium bromide was dripped into a mixture of 5.44 g of trans-4-(4-chloro-3-fluorophenyl) -1-n-propyl-1-silacyclohexane, 80 mg of 1,3-bis(diphenylphosphino)propane nickel (II) chloride and 30 ml of tetrahydrofuran, and the resulting mixture was stirred for 20 hours at 50° C. After a conventional after treatment, the reaction mixture was purified by means of silica-gel chromatography to obtain 6.42 g (yield 70%) of the target product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05578244 |
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| Source dataset | uspto-grants-1996_11 |
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| ORD ID | ord-2b5db8a77cbe4250a4799d872ba30171 |
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| Source note | uspto-grants-1996_11 |
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