1-Bromopentane → HCID 178447745, compound

Participants

Reaction Steps

15.1 g (100 mmol) of n-pentyl bromide was dripped into a mixture of 2.4 g of magnesium (100 mmol) and 60 ml of tetrahydrofuran (hereafter referred to as "THF") to obtain a Grignard's reagent. This solution was then dripped into a 300 ml THF solution of 40.9 g of 4-(2-(4-chloro-4-silacyclohexyl)ethyl)-4'-(4-fluorophenyl)biphenyl. The reaction mixture thus obtained was a mixture of trans isomers and cis isomers with respect to the silacyclohexane ring. After a conventional after treatment, they were separated by means of chromatography to obtain 38.1 g (yield 93%) of the target product.

Provenance & Evidence