1-Bromo-3-chloropropane → HCID 23368058, compound

Participants

Reaction Steps

1.5 g (10 mmol) of 2-hydroxy-5,6,7,8-tetrahydroquinoxaline was dissolved in 40 ml of acetonitrile. To the resultant solution were added 2.76 g (20 mmol) of potassium carbonate and 1.19 ml (12 mmol) of 1-bromo-3-chloropropane. The resultant mixture was heated under reflux for 2 hours and then, subjected to filtration to thereby filter off insoluble substances. The solvent of the filtrate was distilled off in vacuo to thereby obtain a residue. The obtained residue was purified by silica gel column chromatography. That is, the residue was charged in a column of 42 g of silica gel (Art7734, manufactured and sold by E. Merck, Darmstadt) and eluted with chloroform, to thereby obtain 1.47 g of 2-(3-chloropropoxy)-5,6,7,8-tetrahydroquinoxaline (yield: 67%).

Provenance & Evidence