Sodium Iodide → HCID 23368052, compound

Participants

Reaction Steps

227 mg (1 mmol) of 2-(3-chloropropoxy)-5,6,7,8-tetrahydroquinoxaline was dissolved in 10 ml of acetonitrile. To the resultant solution were added 208 mg (1.5 mmol) of potassium carbonate, 196 mg (1.2 mmol) of 1-(2-pyridyl)piperazine and 149 mg (1 mmol) of sodium iodide, and the resultant mixture was heated under reflux for 15 hours. Then, the mixture was subjected to filtration to filter off insoluble substances, which were then washed with acetonitrile, to thereby obtain a filtrate. The solvent of the filtrate was distilled off in vacuo to thereby obtain a residue. The obtained residue was purified by silica gel column chromatography. That is, the residue was charged in a column of 20 g of silica gel (Art7734, manufactured and sold by E. Merck, Darmstadt) and eluted with chloroform-methanol (100:1), to thereby obtain 279 mg of 2-[3-{4-(2-pyridyl)-1-piperazinyl}propoxy]-5,6,7,8-tetrahydroquinoxaline (yield: 79%).

Provenance & Evidence