Water → HCID 22902188, compound

HRID 1901492Notes

Reaction equation

HRID 1901492 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:18]2[C:13](=[C:14]([CH:22]=[CH2:23])[C:15]([F:21])=[C:16]([F:20])[C:17]=2[F:19])[C:12](=[O:24])[C:11]([C:25]([O:27]CC)=[O:26])=[CH:10]1.O.S(=O)(=O)(O)O>C(O)(=O)C>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:18]2[C:13](=[C:14]([CH:22]=[CH2:23])[C:15]([F:21])=[C:16]([F:20])[C:17]=2[F:19])[C:12](=[O:24])[C:11]([C:25]([OH:27])=[O:26])=[CH:10]1

Participants

5

Reactant 3

HCID 962WaterHCID 1118Sulfuric AcidHCID 22924386HCID 22924386, compound

Product 1

HCID 22902188HCID 22902188, compoundYield 69.8%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

2 g of the product of Example C are refluxed for 2 hours in a mixture of 15 ml of glacial acetic acid, 1.5 ml of water and 0.7 ml of concentrated sulphuric acid. The product is filtered off with suction at room temperature, washed with water and dried. 1.3 g of the title compound are obtained (71% of theory).

Workup

  1. filtrationThe product is filtered off with suction at room temperature
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-b0adb27dfaef415ab8889d476aa77aea
Source dataset
uspto-grants-1996_11
Patent number
US05578604

Reaction notes

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