HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-bromo-4-methylaminosulfonylmethyl-N-trifluoroacetylaniline → (R)-1-(N-Benzyloxycarbonylpyrrolidin-2-yl)-3-(N-(2-bromo-4-methylaminosulfonylmethylphenyl)-N-trifluoroacetylamino)propene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-bromo-4-methylaminosulfonylmethyl-N-trifluoroacetylaniline | HCID 11003296 | — |
| Reactant | (R)-1-(N-Benzyloxycarbonylpyrrolidin-2-yl)-3-hydroxypropene | HCID 54485243 | — |
| Product | (R)-1-(N-Benzyloxycarbonylpyrrolidin-2-yl)-3-(N-(2-bromo-4-methylaminosulfonylmethylphenyl)-N-trifluoroacetylamino)propene | HCID 54094024 | 44% |
Reaction Steps
(R)-1-(N-Benzyloxycarbonylpyrrolidin-2-yl)-3-hydroxypropene and 2-bromo-4-methylaminosulfonylmethyl-N-trifluoroacetylaniline were used. Column chromatography using elution with 4% acetone in methylene chloride afforded the title compound as a white foam (44%): FAB LRMS (m/z, relative intensity) 620 ([MH+ with 81Br], 618 ([MH+ with 79Br], 98), 576 (50), 574 (63), 512 (17), 484 (33).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05578612 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-3823d9b6e4684f7e86c5c2a3484aff89 |
| Source note | uspto-grants-1996_11 |