Sodium Hydroxide → HCID 23368580, compound

HRID 1901588Notes

Reaction equation

HRID 1901588 reaction equation
[C:1]([O:5][C:6]([CH:8]([NH:19][CH3:20])[C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=1)[C:12]([O:14]C)=[O:13])=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+]>CO>[C:1]([O:5][C:6]([CH:8]([NH:19][CH3:20])[C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=1)[C:12]([OH:14])=[O:13])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 23368587HCID 23368587, compound

Product 1

HCID 23368580HCID 23368580, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of the product from Step E (0.35 g) in methanol was added 5% sodium hydroxide. After stirring for 2 h the methanol was evaporated and the aqueous layer was adjusted to pH 3 with 2% potassium hydrogen sulfate. The aqueous layer was extracted with ethyl acetate several times. The ethyl acetate layer was washed with saturated sodium chloride, dried over magnesium sulfate, and concentrated in vacuo to yield the title compound.

Workup

  1. customwas evaporated
  2. extractionThe aqueous layer was extracted with ethyl acetate several times
  3. washThe ethyl acetate layer was washed with saturated sodium chloride
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-b3a1f40c4b8149ce938c0f6c251bab9c
Source dataset
uspto-grants-1996_11
Patent number
US05578629

Reaction notes

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