Hydrochloric Acid → HCID 178518988, compound

Participants

Reaction Steps

To a suspension of 2.44 g of 5-fluorosalicylhydroxamic acid in 22 ml of tetrahydrofuran is added 1.83 g of thionyl chloride at 10° C., and they are subjected to reaction at 20°-25° C. for one hour. Subsequently, at 10°-15° C., 4.67 g of triethylamine is dropped over 30 minutes, and thereafter, reaction is effected at 20°-25° C. for one hour. To the reaction mixture is added 200 ml of water, and the pH is adjusted to 3 with 2N hydrochloric acid. The crystals precipitated are collected by filtration to obtain 1.32 g of colorless, crystalline 5-fluoro-3-hydroxy-1,2-benzoisoxazole having a melting point of 201°-203° C.

Provenance & Evidence