3-Hydroxypyridine → HCID 23368445, compound

Participants

Reaction Steps

To a solution of 0.5 g of 3-(2-tert-butoxycarbonylamino-3-hydroxypropoxy)-1,2-benzoisoxazole in 5 ml of tetrahydrofuran are added 0.154 g of 3-hydroxypyridine, 0.553 g of triphenylphosphine and 0.33 ml of diethyl azodicarboxylate at room temperature with ice-cooling, and they are subjected to reaction at room temperature for eight hours. The solvent is removed from the reaction mixture by distillation under reduced pressure, and the residue obtained is purified by a silica gel column chromatography [eluant:n-hexane:ethyl acetate=4:1], to obtain 0.32 g of oily 3-[2-tert-butoxycarbonylamino-3-(3-pyridyloxy)propoxy]-1,2-benzoisoxazole.

Provenance & Evidence