HCID 23368541, compound → HCID 23368571, compound

Participants

Reaction Steps

In 10 ml of 2-propanol is dissolved 3-(2-tert-butoxycarbonylamino-3-hydrazinocarbonyloxypropoxy)-5-chloro-1,2-benzoisoxazole, and 12.8 ml of a 2-propanol solution (7.5N) of hydrogen chloride is added thereto, after which they are subjected to reaction at 20°-25° C. for 1.5 hours. The solvent is removed from the reaction mixture by distillation under reduced pressure, and the crystals obtained are washed with 5 ml of ethyl acetate and then collected by filtration, to obtain 0.52 g of colorless, crystalline 3-(2-amino-3-hydrazinocarbonyloxypropoxy)-5-chloro-1,2-benzoisoxazole hydrochloride having a melting point of 190°-191° C.

Provenance & Evidence