HCID 23368458, compound → HCID 23368502, compound

Participants

Reaction Steps

To a suspension of 0.40 g of 3-(2-amino-3-methoxypropoxy)-5-benzyloxy-1,2-benzoisoxazole hydrochloride in 20 ml of methanol is added 0.1 g of 5% palladium carbon, and they are subjected to catalytic reduction at 20°-25° C. under atmospheric pressure. The 5% palladium carbon is removed from the reaction mixture by filtration, and the solvent is removed from the filtrate by distillation under reduced pressure. The residue obtained is crystallized from 2-propanol, and the crystals are collected by filtration, to obtain 0.16 g of colorless, crystalline 3-(2-amino-3-methoxypropoxy)-5-hydroxy-1,2-benzoisoxazole hydrochloride having a melting point of 187°-190° C.

Provenance & Evidence