Hydrochloric Acid → HCID 67733454, compound

Participants

Reaction Steps

To a solution of 2.41 g of (R)-5-chloro-3-(3-methylthio-2-tritylaminopropoxy)-1,2-benzoisoxazole in 5 ml of methanol is added 6.0 ml of a 2-propanol solution (6.5M) of hydrogen chloride at room temperature, and they are subjected to reaction at the same temperature for three hours, after which the solvent is removed by distillation under reduced pressure. Ethyl acetate is added to the residue obtained and the crystals precipitated are collected by filtration and dried, to obtain 0.72 g of colorless, crystalline (R)-3-(2-amino-3-methylthiopropoxy)-5-chloro-1,2-benzoisoxazole hydrochloride having a melting point of 195.0°-198.2° C. (decomp.).

Provenance & Evidence