m-Chloroperbenzoic acid → HCID 67733447, compound

Participants

Reaction Steps

To a solution of 0.54 g of (R)-3-(2-amino-3-methylthiopropoxy)-5-chloro-1,2-benzoisoxazole in 5 ml of methylene chloride is added 0.43 g of m-chloroperbenzoic acid with ice-cooling, and they are subjected to reaction at the same temperature for 30 minutes, after which 0.21 g of m-chloroperbenzoic acid is added and they are subjected to reaction for a further 30 minutes at the same temperature. After completion of the reaction, a saturated aqueous sodium hydrogencarbonate solution is added and shaken, after which the organic layer is separated. The separated organic layer is washed with a saturated saline solution and dried over anhydrous magnesium sulfate, and the solvent is removed by distillation under reduced pressure. The residue obtained is purified by a column chromatography [eluant:chloroform:methanol=20:1], to obtain 0.14 g of oily (R)-3-(2-amino-3-methanesulfinylpropoxy)-5-chloro-1,2-benzoisoxazole (Compound No. 139-1) and 0.38 g of oily (R)-3-(2-amino-3-methanesulfonylpropoxy)-5-chloro-1,2-benzoisoxazole (Compound No. 139-2).

Provenance & Evidence