Hydrochloric Acid → HCID 23368565, compound

Participants

Reaction Steps

To a solution of 0.4 g of 5-chloro-3-(2-tert-butoxycarbonylamino-3-sulfamoyloxypropoxy)-1,2-benzoisoxazole in 10 ml of methanol is added 5 ml of a dioxane solution (3.2N) of hydrogen chloride at room temperature and they are subjected to reaction at the same temperature for 24 hours, after which the solvent is removed by distillation under reduced pressure. To the residue obtained is added 10 ml of ethyl acetate, and the crystals precipitated are collected by filtration, to obtain 0.24 g of colorless, crystalline 3-(2-amino-3-sulfamoyloxypropoxy)-5-chloro-1,2-benzoisoxazole hydrochloride having a melting point of 150.5°-152.5° C. (decomp.).

Provenance & Evidence