Imidazole → Benzyl N-[2-t-Butyldimethylsilyloxy-1(R)-methylethyl]carbamate

Participants

Reaction Steps

A procedure similar to that described in Preparation 8 was repeated, except that 12.54 g of (5)-2-benzyloxycarbonylaminopropanol (prepared as described in Preparation 23), 9.97 g of t-butyldimethylsilyl chloride, 4.90 g of imidazole and 150 ml of anhydrous dimethylformamide were used, to give 16.43 g of the title compound having an Rf value of 0.54 (on silica gel thin layer chromatography, using a 1:4 by volume mixture of ethyl acetate and hexane as the developing solvent).

Provenance & Evidence