Benzyl N-[2-t-Butyldimethylsilyloxy-1(R)-methylethyl]carbamate → (R)-1-((tert-butyldimethylsilyl)oxy)propan-2-amine

Participants

Reaction Steps

A procedure similar to that described in Preparation 9 was repeated, except that 16.4 g of benzyl N-[2-t-butyldimethylsilyloxy-1(R)-methylethyl]carbamate (prepared as described in Preparation 24), 3.5 g of 10% w/w palladium-on-carbon and 100 ml of ethanol were used, to give 8.55 g of the title compound having an Rf value of 0.27 (on silica gel thin layer chromatography, using a 1:3 by volume mixture of ethyl acetate and hexane as the developing solvent) and having [α]D =-10.1° (methanol, c=1.155).

Provenance & Evidence