Dimethylformamide → HCID 53837599, compound

Participants

Reaction Steps

A procedure similar to that described in Preparation 11 was repeated, except that 0.82 g of 1(R)-(3-chlorophenoxymethyl)-2-[2-t-butyldimethylsilyloxy-1(S)-methylethylamino]ethanol (prepared as described in Preparation 34), 0.43 g of N,N'-carbonyldiimidazole and 10 ml of anhydrous dimethylformamide were used, to give 0.85 g of the title compound having an Rf value of 0.25 (on silica gel thin layer chromatography, using a 1:2 by volume mixture of ethyl acetate and hexane as the developing solvent) and having [α]D =-33.4° (methanol, c=1.040).

Provenance & Evidence