HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tributylphosphine → HCID 15383950, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tributylphosphine | HCID 13831 | — |
| Reactant | 1,1'-(Azodicarbonyl)dipiperidine | HCID 73042 | — |
| Reactant | 5-(4-Hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione | HCID 2818126 | — |
| Reactant | HCID 67741583 | HCID 67741583 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | HCID 15383950 | HCID 15383950 | 29% |
Reaction Steps
A procedure similar to that described in Preparation 6 was repeated, except that 405 mg of tributylphosphine, 25 ml of anhydrous benzene, 700 mg of 2(S)-[5(S)-(3-chlorophenoxymethyl)-2-oxooxazolidin-3-yl]propanol (prepared as described in Preparation 40), 505 mg of azodicarbonyldipiperidine and 745 mg of 5-(4-hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione were used, to give 340 mg of the title compound, melting at 80° C. to 84° C. and having [α]D =+25.9° (methanol, c=0.96).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05578620 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-94f51e1e5abc477fad586202a43e8e75 |
| Source note | uspto-grants-1996_11 |