Tetrabutylammonium Fluoride → 2-Oxazolidinone, 5-[(3-chlorophenoxy)methyl]-3-(2-hydroxy-1-methylethyl)-, [R-(R*,R*)]-

Participants

Reaction Steps

A procedure similar to that described in Preparation 5(b) was repeated, except that 3.25 g of 3-[2-t-butyldimethylsilyloxy-1(R)-methylethyl]-5(R)-(3-chlorophenoxymethyl)oxazolidin-2-one (prepared as described in Preparation 43), 24 ml of tetrabutylammonium fluoride (26% w/v in tetrahydrofuran) and 30 ml of anhydrous tetrahydrofuran were used, to give 2.28 g of the title compound, melting at 76° C. to 78° C. and having [α]D =-65.4° (methanol, c=1.060).

Provenance & Evidence