HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tributylphosphine → HCID 15383951, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tributylphosphine | HCID 13831 | — |
| Reactant | 1,1'-(Azodicarbonyl)dipiperidine | HCID 73042 | — |
| Reactant | 5-(4-Hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione | HCID 2818126 | — |
| Reactant | 2-Oxazolidinone, 5-[(3-chlorophenoxy)methyl]-3-(2-hydroxy-1-methylethyl)-, [R-(R*,R*)]- | HCID 67741586 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | HCID 15383951 | HCID 15383951 | 34.1% |
Reaction Steps
A procedure similar to that described in Preparation 6 was repeated, except that 526 mg of tributylphosphine, 25 ml of anhydrous benzene, 900 mg of 2(R)-[5(R)-(3-chlorophenoxymethyl)-2-oxooxazolidin-3-yl]propanol (prepared as described in Preparation 44), 656 mg of azodicarbonyldipiperidine and 1.21 g of 5-(4-hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione were used, to give 0.65 g of the title compound, melting at 74° C. to 81° C. and having [α]D =-29.0° (methanol, c=1.000).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05578620 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-676eb8a37b274db7913a37fafece26f5 |
| Source note | uspto-grants-1996_11 |