HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Epoxypropyl 4'-methoxyphenyl ether → 1-(4-Methoxyphenoxymethyl)-2-(2-t-butyldimethylsilyloxy-1-methylethylamino)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Epoxypropyl 4'-methoxyphenyl ether | HCID 16646 | — |
| Reactant | (S)-2-Amino-tert-butyldimethylsilyloxypropane | HCID 21474737 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(4-Methoxyphenoxymethyl)-2-(2-t-butyldimethylsilyloxy-1-methylethylamino)ethanol | HCID 21474700 | 58.2% |
Reaction Steps
A procedure similar to that described in Preparation 10 was repeated, except that 3.22 g of 2-t-butyldimethylsilyloxy-1-methylethylamine, 3.00 g of 4-methoxyphenoxymethyloxirane and 30 ml of ethanol were used, to give 3.58 g of the title compound having an Rf value of 0.15 (on silica gel thin layer chromatography, using ethyl acetate as the developing solvent).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05578620 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-dca3edc3897d4615b27d111de924c071 |
| Source note | uspto-grants-1996_11 |