Tetrabutylammonium Fluoride → 2-[5-(4-Methoxyphenoxymethyl)-2-oxooxazolidin-3-yl]propanol

Participants

Reaction Steps

A procedure similar to that described in Preparation 5(b) was repeated, except that 1.26 g of 3-(2-t-butyldimethylsilyloxy-1-methylethyl)-5-(4-methoxyphenoxymethyl)oxazolidin-2-one (polar isomer), obtained as described in Preparation 76, 9.6 ml of tetrabutylammonium fluoride (26% w/v in tetrahydrofuran) and 10 ml of anhydrous tetrahydrofuran were used, to give 0.86 g of the title compound, melting at 62° C. to 67° C., from the polar diastereomer.

Provenance & Evidence