HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → benzyl N-(1-hydroxy-2-methylpropan-2-yl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Benzyl chloroformate | HCID 10387 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Amino-2-methyl-1-propanol | HCID 11807 | — |
| Solvent | Water | HCID 962 | — |
| Product | benzyl N-(1-hydroxy-2-methylpropan-2-yl)carbamate | HCID 12325553 | 100.3% |
Reaction Steps
A procedure similar to that described in Preparation 7 was repeated, except that 7.00 g of 2-amino-2-methylpropanol, 13.47 g of benzyloxycarbonyl chloride, 13.13 g of potassium carbonate, 35 ml of ethyl acetate and 35 ml of water were used, to give 17.59 g of the title compound having an Rf value of 0.72 (on silica gel thin layer chromatography, using a 3:1 by volume mixture of ethyl acetate and hexane as the developing solvent).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05578620 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-a775360ec1194f0f9718f6a4ebd7d17c |
| Source note | uspto-grants-1996_11 |