HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → Benzyl N-[2-t-Butyldimethylsilyloxy-1,1-dimethylethyl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | benzyl N-(1-hydroxy-2-methylpropan-2-yl)carbamate | HCID 12325553 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Benzyl N-[2-t-Butyldimethylsilyloxy-1,1-dimethylethyl]carbamate | HCID 21474722 | 97.1% |
Reaction Steps
A procedure similar to that described in Preparation 8 was repeated, except that 10.00 g of 2-benzyloxycarbonylamino-2-methylpropanol, 7.35 g of imidazole, 150 ml of anhydrous dimethylformamide and 8.14 g of t-butyldimethylsilyl chloride were used, to give 14.68 g of the title compound having an Rf value of 0.73 (on silica gel thin layer chromatography, using a 1:4 by volume mixture of ethyl acetate and hexane as the developing solvent).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05578620 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-1e9dd6b2f31b4322a6baafabc16a8550 |
| Source note | uspto-grants-1996_11 |