HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 3-(5-Phenoxymethyl-2-oxooxazolidin-3-yl)propanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Lithium borohydride | HCID 4148881 | — |
| Reactant | Ethyl 3-(5-phenoxymethyl-2-oxooxazolidin-3-yl)propionate | HCID 21474742 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(5-Phenoxymethyl-2-oxooxazolidin-3-yl)propanol | HCID 21474781 | 100.4% |
Reaction Steps
A procedure similar to that described in Preparation 5(a) was repeated, except that 1.64 g of ethyl 3-(5-phenoxymethyl-2-oxooxazolidin-3-yl)propionate (prepared as described in Preparation 113), 15 ml of anhydrous tetrahydrofuran, 244 mg of lithium borohydride and 179 mg of anhydrous methanol were used, to give 1.41 g of the title compound having an Rf value of 0.28 (on silica gel thin layer chromatography, using ethyl acetate as the developing solvent).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05578620 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-ceba9107bc94485ab2bea7e8ba6e2cdf |
| Source note | uspto-grants-1996_11 |