HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tributylphosphine → 5-{4-[3-(5-Phenoxymethyl-2-oxooxazolidin-3-yl)propoxy]benzyl}-3-triphenylmethylthiazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tributylphosphine | HCID 13831 | — |
| Reactant | 1,1'-(Azodicarbonyl)dipiperidine | HCID 73042 | — |
| Reactant | 5-(4-Hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione | HCID 2818126 | — |
| Reactant | 3-(5-Phenoxymethyl-2-oxooxazolidin-3-yl)propanol | HCID 21474781 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 5-{4-[3-(5-Phenoxymethyl-2-oxooxazolidin-3-yl)propoxy]benzyl}-3-triphenylmethylthiazolidine-2,4-dione | HCID 21474751 | 55.2% |
Reaction Steps
A procedure similar to that described in Preparation 6 was repeated, except that 1.29 g of tributylphosphine, 30 ml of anhydrous benzene, 2.98 g of 5-(4-hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione, 1.61 g of azodicarbonyldipiperidine and 1.33 g of 3-(5-phenoxymethyl-2-oxooxazolidin-3-yl)propanol (prepared as described in Preparation 114) were used, to give 2.04 g of the title compound, melting at 70° C. to 73° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05578620 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-3286f50403aa468cbf833b1985a39491 |
| Source note | uspto-grants-1996_11 |