反应详情

To a solution of 5-formyl-2,2'-bithiophene (20 g) in methanol (50 ml) was added sodium borohydride. The reaction mixture was stirred at room temperature and monitored with thin layer chromatography until the reaction completed. After removal of methanol, water was added to dissolve inorganic salts and extracted with dichloromethane. The extract was washed with brine, dried over anhydrous magnesium sulfate, concentrated to give product (20.1 g, 99%), melting point 52°-53° C.

1. customAfter removal of methanol, water
2. additionwas added
3. dissolutionto dissolve inorganic salts
4. extractionextracted with dichloromethane
5. washThe extract was washed with brine
6. dry with materialdried over anhydrous magnesium sulfate
7. concentrationconcentrated