HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-2-methylaniline → N-tert-butoxycarbonyl-5-chloro-2-methylaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-2-methylaniline | HCID 7260 | — |
| Reactant | Di-tert-butyl dicarbonate | HCID 90495 | — |
| Reactant | tert-Butyl (4-chloro-2-methylphenyl)carbamate | HCID 14710386 | — |
| Product | N-tert-butoxycarbonyl-5-chloro-2-methylaniline | HCID 4935530 | 77% |
Reaction Steps
N-tert-Butoxycarbonyl-4-chloro-2-methylaniline. By the procedure in Example 1, Part C, 28.3 g (0.2 mole) of 5-chloro-2-methylaniline was reacted with 48.1 g (0.22 mol) of di-tert-butyl dicarbonate to give 37.1 g (77% yield) of N-tert-butoxycarbonyl-5-chloro-2-methylaniline melting at 100°-102° C., after crystallizing from hexane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05578634 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-14e555cbd48b4838a2711bdd127fa50e |
| Source note | uspto-grants-1996_11 |