HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1-Bromoethyl)benzene → HCID 23368756, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1-Bromoethyl)benzene | HCID 11454 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 10689282 | HCID 10689282 | — |
| Reactant | Ethyl (5-methoxy-2-methyl-1H-indol-3-yl)acetate | HCID 10729163 | — |
| Product | HCID 23368756 | HCID 23368756 | 22% |
Reaction Steps
5-Methoxy-2-methyl-1-(1-phenylethyl)-1H-indole-3-acetic acid ethyl ester. Using the procedure described in Example 1, Part F, 494 mg (2 mmol) of 5-methoxy-2-methyl-1H-indole-3-acetic acid ethyl ester was reacted with 80 mg (2 mmol) of 60% NaH/mineral oil and 0.27 mL (2 mmol) of (1-bromoethyl)benzene and after chromatography on silica (eluting with 25% EtOAc/hexane) there was obtained 160 mg (22%) of 5-methoxy-2-methyl-1-(1-phenylethyl)1H-indole-3-acetic acid acid ethyl ester as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05578634 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-9c37a11f53fb4f88b92f8cf51efdc69a |
| Source note | uspto-grants-1996_11 |