HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boron tribromide → HCID 23368791, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | 1-(4-Chlorobenzyl)-5-methoxy-2-methylindole-3-acetic acid | HCID 4059895 | — |
| Reactant | 1-[(4-Chlorophenyl)methyl]-5-hydroxy-2-methyl-1H-indole-3-acetic acid methyl ester | HCID 53817482 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 23368791 | HCID 23368791 | — |
Reaction Steps
1-[(4-Chlorophenyl)methyl]-5-hydroxy-2-methyl-1H-indole-3-acetic acid methyl ester. Using the methods in Example 63, Part C, 1.2 g (3.5 mmol) of 1-[(4-chlorophenyl)methyl]-5-methoxy-2-methyl-1H-indole-3-acetic acid was treated with 15 mL of 1M BBr3 in CH2Cl2 to give crude 1-[(4-chlorophenyl)-methyl]-5-hydroxy-2-methyl-1H-indole-3-acetic acid which was treated with sulfuric acid in MeOH to give 1.2 g of 1-[(4-chlorophenyl)methyl]-5-hydroxy-2-methyl-1H-indole-3-acetic acid methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05578634 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-3236222f72e941c788dc77e1abfa8ce4 |
| Source note | uspto-grants-1996_11 |