HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-[N-(Tosyl)-N-(dimethylcarbamoylmethyl)amino]-5-chlorophenyl cyclohexyl ketone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Bromo-2-methylpropanamide | HCID 101235 | — |
| Reactant | 5-Chloro-2-tosylaminophenyl cyclohexyl ketone | HCID 53778489 | — |
| Product | 2-[N-(Tosyl)-N-(dimethylcarbamoylmethyl)amino]-5-chlorophenyl cyclohexyl ketone | HCID 54361654 | — |
Reaction Steps
4.3 g of 5-chloro-2-tosylaminophenyl cyclohexyl ketone are placed in 20 ml of DMF in the presence of 360 mg of 80% sodium hydride, after 15 minutes at RT 5.4 g of the compound prepared in step B are added and the mixture is stirred overnight at RT. The reaction medium is poured into water and the precipitate is filtered off and then taken up with DCM, dried and concentrated. The expected product crystallizes from isopropyl ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05578633 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-b94038cff61c46ad94432bf272d09d02 |
| Source note | uspto-grants-1996_11 |