HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → N-Benzyl-2-bromo-N-methylacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | N-Methylbenzylamine | HCID 7669 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Bromoacetyl bromide | HCID 61147 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-Benzyl-2-bromo-N-methylacetamide | HCID 150681 | 100.1% |
Reaction Steps
At 0° C., a solution of 10 g of bromoacetyl bromide in 20 ml of DCM is added to a solution of 6 g of methylbenzylamine and 5 g of triethylamine in 50 ml of DCM. After one night at RT, ether is added, the precipitate formed is filtered off and the filtrate is concentrated to give 12 g of the expected product in crude form.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05578633 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-5788b517ea524cf0b335cdbb6c0a6a02 |
| Source note | uspto-grants-1996_11 |