反应详情

(3S ,4S)-3-[(1R)-1-t-Butyldimethylsilyloxyethyl]-4-[(1R)-1-carboxyethyl]-2-azetidinone (995 mg, 3.3 mmol), benzylmercaptan (409 mg, 3.5 mmol) and 2-chloro-1,3-dimethylimidazolinium chloride (592 mg, 3.5 mmol) are dissolved in methylene chloride (3 ml), and thereto is added dropwise pyridine (550 mg, 7.0 mmol) under ice-cooling. The mixture is stirred at room temperature for 10 hours. The reaction solution is treated in the same manner as in Reference Example 3 to give (3S,4S)-3-[(1R)-1-t-butyldimethylsilyloxyethyl]-4-[(1R)-1-(benzylthiocarbonyl)ethyl]-2-azetidinone (868 mg).

1. temperaturecooling
2. additionThe reaction solution is treated in the same manner as in Reference Example 3