N-((1,1-dimethylethoxy)carbonyl)-2-methyl-alanine → HCID 23367875, compound

HRID 1902148Notes

Reaction equation

HRID 1902148 reaction equation
CC(OC(=O)[NH:7][CH:8]([C:17]([N:19]1[CH2:24][CH2:23][C:22]2([C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[C:26](=[O:33])[CH2:25]2)[CH2:21][CH2:20]1)=[O:18])[CH:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH3:10])(C)C.[C:35]([NH:42][C:43]([CH3:48])([C:45]([OH:47])=O)[CH3:44])([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36]>>[O:33]=[C:26]1[C:27]2[C:32](=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:22]2([CH2:21][CH2:20][N:19]([C:17]([CH:8]([NH:7][C:45](=[O:47])[C:43]([NH:42][C:35]([O:37][C:38]([CH3:39])([CH3:40])[CH3:41])=[O:36])([CH3:44])[CH3:48])[CH:9]([C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH3:10])=[O:18])[CH2:24][CH2:23]2)[CH2:25]1

Participants

3

Reactant 2

HCID 2733845N-((1,1-dimethylethoxy)carbonyl)-2-methyl-alanineHCID 70343694HCID 70343694, compound

Product 1

HCID 23367875HCID 23367875, compoundYield 64.8%

Procedure

The title compound (236 mg, 0.431 mmol) was prepared from 316 mg (0.665 mmol) of the intermediate from Step A and 148 mg (0.731 mmol) of Boc alpha methyl alanine according to the procedure described in Example 1 (Step A).

Sources & evidence

ORD record
ord-c2d85a02926b4e198b07b441d610635e
Source dataset
uspto-grants-1996_11
Patent number
US05578593

Reaction notes

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