Sodium borohydride → HCID 23367756, compound

HRID 1902149Notes

Reaction equation

[ClH:1].[CH3:2][C:3]1([CH3:37])[C:11]2([CH2:16][CH2:15][N:14]([C:17]([CH:19]([NH:29][C:30](=[O:35])[C:31]([NH2:34])([CH3:33])[CH3:32])[CH2:20][O:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[O:18])[CH2:13][CH2:12]2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]1=[O:36].[BH4-].[Na+]>>[ClH:1].[CH3:2][C:3]1([CH3:37])[C:11]2([CH2:16][CH2:15][N:14]([C:17]([CH:19]([NH:29][C:30](=[O:35])[C:31]([NH2:34])([CH3:32])[CH3:33])[CH2:20][O:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[O:18])[CH2:13][CH2:12]2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]1[OH:36]

Participants

Reactant 2

HCID 4311764Sodium borohydride

HCID 23367982HCID 23367982, compound

Product 1

HCID 23367756HCID 23367756, compoundYield 63.8%

Procedure

The title compound (16.1 mg, 0.030 mmol) was prepared from the intermediate obtained from Example 9, Step D (25 mg, 0.047 mmol) according to the procedure described for Example 5 (Step A) except that a large excess of sodium borohydride was used instead of a slight excess.

Sources & evidence

ORD record: ord-12ee0e7136de4a7b864d7138016b7acb
Source dataset: uspto-grants-1996_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05578593

Reaction notes

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