HCID 22867459, compound → HCID 22867359, compound

HRID 1902152Notes

Reaction equation

HRID 1902152 reaction equation
[ClH:1].[N:2]1([C:16]([C@H:18]([NH:26][C:27](=[O:32])[C:28]([NH2:31])([CH3:30])[CH3:29])[CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])[CH2:7][CH2:6][C:5]2([C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH:9]=[CH:8]2)[CH2:4][CH2:3]1>[Pd]>[ClH:1].[N:2]1([C:16]([C@H:18]([NH:26][C:27](=[O:32])[C:28]([NH2:31])([CH3:30])[CH3:29])[CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])[CH2:7][CH2:6][C:5]2([C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH2:9][CH2:8]2)[CH2:4][CH2:3]1

Participants

3

Reactant 1

HCID 22867459HCID 22867459, compound

Product 1

HCID 22867359HCID 22867359, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Prepared from the intermediate obtained from Example 26, Step C (31 mg, 0.068 mmole) by the procedure described in Example 20, Step B (use 10% Pd on carbon instead of Pd(OH)2 to give 30 mg (97%) of the title compound.

Sources & evidence

ORD record
ord-1609747c9d2346b2b06a7c925f133395
Source dataset
uspto-grants-1996_11
Patent number
US05578593

Reaction notes

Loading…