HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → (R)-2-Amino-4-(4-hydroxyphenyl)butanoic acid hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | (2R)-2-[(methoxycarbonyl)amino]-4-(4-methoxyphenyl)-butanoic acid | HCID 13944504 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | (R)-2-Amino-4-(4-hydroxyphenyl)butanoic acid hydrobromide | HCID 56777052 | — |
Reaction Steps
A solution of (2R)-2-[(methoxycarbonyl)amino]-4-(4-methoxyphenyl)-butanoic acid (5.0 g, 18.7 mmol) in 5 mL of 30% HBr in acetic acid was heated at 60° C. overnight. The reaction mixture was cooled to room temperature and the solvent was removed under reduced pressure to give the title compound as an orange solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05578593 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-cd495096f60c472b8b6e9f5ce78a2d6a |
| Source note | uspto-grants-1996_11 |